2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140706
    m-PEG-thiol (MW 2000) 134874-49-0 ≥98.0%
    m-PEG-thiol (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-thiol (MW 2000)
  • HY-40142
    1-N-Boc-3-hydroxyazetidine 141699-55-0 99.03%
    1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
    1-N-Boc-3-hydroxyazetidine
  • HY-119429
    Bis-PEG4-acid 31127-85-2 ≥98.0%
    Bis-PEG4-acid is a PEG PROTAC linker.
    Bis-PEG4-acid
  • HY-W007700
    8-Bromooctanoic acid 17696-11-6 99.89%
    8-Bromooctanoic acid is a PROTAC linker, and can be used for synthesis of PROTAC CYP1B1 degrader-2 (HY-158429).
    8-Bromooctanoic acid
  • HY-W044155
    Azido-PEG2-azide 59559-06-7 98.11%
    Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-azide
  • HY-W007341
    Pentaethylene glycol 4792-15-8 99.58%
    Pentaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Pentaethylene glycol
  • HY-140232
    Boc-NH-PEG7-NH2 206265-98-7 99.83%
    Boc-NH-PEG7-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG7-NH2
  • HY-112559
    Bis-PEG2-acid 19364-66-0 ≥98.0%
    Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-PEG2-acid
  • HY-140182
    Amino-PEG24-acid 2563873-76-5 ≥98.0%
    Amino-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG24-acid
  • HY-W067489
    NH2-PEG1-CH2CH2-Boc 1260092-46-3 99.83%
    NH2-PEG1-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-PEG1-CH2CH2-Boc
  • HY-130504
    Propargyl-PEG1-acid 55683-37-9
    Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM. Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG1-acid
  • HY-140217
    Azido-PEG10-amine 912849-73-1
    Azido-PEG10-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG10-amine
  • HY-W040214
    m-PEG4-Amine 85030-56-4 98.80%
    m-PEG4-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG4-Amine
  • HY-112496
    Cl-C6-PEG4-O-CH2COOH 1799506-30-1 ≥98.0%
    Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).
    Cl-C6-PEG4-O-CH2COOH
  • HY-W034597
    20-(tert-Butoxy)-20-oxoicosanoic acid 683239-16-9 ≥98.0%
    20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
    20-(tert-Butoxy)-20-oxoicosanoic acid
  • HY-140762
    Azido-PEG24-NHS ester 2375600-46-5
    Azido-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG24-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG24-NHS ester
  • HY-140932
    Biotin-PEG4-hydrazide 756525-97-0 99.88%
    Biotin-PEG4-hydrazide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG4-hydrazide
  • HY-W040133
    Mal-amido-PEG8-NHS ester 756525-93-6 99.23%
    Mal-amido-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG8-NHS ester
  • HY-43048
    2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid 2231744-57-1
    2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid is a PROTACT linker in PROTAC SMARCA2/4-degrader-34 (HY-169279).
    2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid
  • HY-140231
    Boc-NH-PEG6-amine 1091627-77-8
    Boc-NH-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG6-amine
PROTAC Linkers Isoform Comparison

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